The Ontario Institute for Cancer Research

Dr. Sachdev Sidhu

Associate Investigator

Research Description

How cells grow and how they work depends on signals that are mediated by interactions among proteins in the body. Improper regulation of signaling proteins is associated with the rise and progression of cancer and other diseases.  A major area of modern biology is concerned with figuring out how protein networks operate and then using this knowledge to create new therapies to help people living with the disease. 

The Sidhu lab uses combinatorial libraries to develop synthetic peptides, proteins and antibodies that can be used to track and modulate signaling proteins. These synthetic substances are invaluable tools for elucidating the function of proteins in normal and diseased states and may even be used as cancer therapeutics.

Contact Information

Telephone
416-946-0863

Mailing Address
Donnelly Centre for Cellular and Biomolecular Research
160 College Street
Toronto, Ontario
Canada M5S 3E1

Current

2008 - Associate Investigator, OICR.
2008 - Associate Professor, Banting and Best Department of Medical Research, University of Toronto.


Background        

2004 - 2008 Senior Scientist, Department of Protein Engineering, Genentech, Inc..
1998 - 2004 Scientist, Department of Protein Engineering, Genentech, Inc..
1998 Postdoctoral Fellow Department of Protein Engineering, Genentech, Inc. Supervisor:  Dr. James A. Wells.
1996 PhD, Biochemistry, Simon Fraser University.

                                             

Selected Publications

  1. Yeh JH, Sidhu SS, Chan AC. Regulation of a late phase of T cell polarity and effector functions by Crtam. Cell.  2008;132: 846-859.
  2. Fellouse FA, Esaki K, Birtalan S, Raptis J, Cancasci VJ, Koide A, Jhurani P, Vasser M, Wiesmann C, Kossiakoff AA, Koide S, Sidhu SS. High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries.  J. Mol. Biol. 2007;373:924-940.
  3. Sidhu SS, Fellouse FA. Synthetic therapeutic antibodies. Nature Chem. Biol. 2006;12:682-688.
  4. Li B, Totpal K, Russell S, Yeh S, Wong WL, Cochran A, Ashkenazi A, Hymowitz S, Sidhu SS. Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists. J. Mol. Biol. 2006;361:522-536.
  5. Fellouse FA, Peden AA, Sidhu SS. Molecular recognition by a binary code. J. Mol. Biol. 2005;348:1153-1162.

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