Dr. John McLaughlin
Interim Director and Lead Cancer Scientist, Ontario Health Study
Program Description
OICR has partnered with other organizations in creating and developing the Ontario Health Study (OHS), a large prospective epidemiological study that will contain comprehensive data provided by 150,000 adult volunteers from across the province. The OHS will be a resource used to do research that aims to improve the understanding of causes and risk factors that initiate and accelerate cancer and other chronic diseases, with the ultimate goal of leading to improved prevention strategies. It involves the collection of data and biospecimens (e.g., a blood sample) from individual participants, as well as information on their communities and environment. Recruitment is currently in an early phase, with assessment centres serving as the base for recruitment in three regions of the province, and will ramp up over the coming years. Until a Scientific Director was recruited to OICR in 2010, Dr. McLaughlin served as inaugural Director for the OHS during its development and launch, with operations and scientific teams based at Cancer Care Ontario, and with the interdisciplinary support of scientists from across Ontario.
Contact Information
Telephone
416-971-9800, ext. 1234
Mailing Address
Cancer Care Ontario
620 University Avenue
Toronto, Ontario
Canada M5G 2L7
Assistant to Dr. McLaughlin
Maureen Muscott
416-971-9800, ext. 3707
Operations Director
Ontario Health Study
Sandra Sinclair
416-971-9800, ext. 3154
Current
| 2010 - | Interim Director and Lead Cancer Scientist, Ontario Health Study, OICR |
| 2008 - | Vice President, Population Studies and Surveillance, Cancer Care Ontario. |
| 2007 - | Professor, Dalla Lana School of Public Health, University of Toronto. |
| 1999 - | Senior Investigator, Samuel Lunenfeld Research Institute at Mount Sinai Hospital, with membership in the Prosserman Centre for Health Research (for molecular and genetic epidemiology), and in the Henry S. Rosenberg Program in Epidemiology and Biostatistics. |
| 1996 - | Continuing (Full) Member of the Graduate Faculty, Graduate Department of Community Health, School of Graduate Studies, University of Toronto. |
Background
| 2007 - 2010 | Program Director, Ontario Health Study, OICR |
| 2005 - 2008 | Vice President, Division of Preventive Oncology, Cancer Care Ontario |
| 2001 - 2007 | Leader, Prosserman Centre for Health Research at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto. |
| 1997 - 2007 | Associate Professor, Department of Public Health Sciences, University of Toronto. |
| 1993 - 1999 | Research Scientist of the National Cancer Institute of Canada, in the Department of Public Health Sciences, University of Toronto. |
| 1993 - 1996 | Epidemiologist, National Cancer Institute of Canada (NCIC) Epidemiology Unit, Department of Preventive Medicine and Biostatistics, University of Toronto. |
| 1989 | PhD (Epidemiology), University of Toronto. |
Selected Publications
1. McLaughlin JR, Risch H, Lubinski J, Moller P, Ghadirian P, Lynch H, Karlan B, Fishman D, Rosen B, Neuhausen S, Offit K, Kauff N, Domchek S, Tung N, Friedman E, Foulkes W, Sun P, Narod S and the Hereditary Ovarian Cancer Clinical Study Group. Risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations. Lancet Oncology. 2007;(8):26-34.
2. Campbell P, Newcomb P, Gallinger S, Cotterchio M, McLaughlin J. Exogenous hormones and colorectal cancer risk in Canada: associations stratified by clinically defined familial risk of cancer. Cancer Causes and Control. 2007;(18):723-33.
3. Hung R, McKay J, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Chen C, Goodman G, Field J, Liloglou T, Xinarianos G, Cassidy A, McLaughlin J, Liu G, Narod S, Krokan H, Shorpen F, Bratt Elvestad M, Hveem K, Vatten L, Linseisen J, Clavel-Chapelon F, Vineis P, Bueno-de-Mesquita HB, Lund E, Martinez C, Bingham S, Rasmuson T, Hainaut P, Riboli E, Ahrens W, Benhamou S, Lagiou P, Trichopoulos D, Holcatova I, Merletti F, Kjaerheim K, Agudo A, Macfarlane G, Talamini R, Simonato L, Lowry R, Conway D, Znaor A, Healy C, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P. A genome-wide association study identifies a susceptibility locus for lung cancer encompassing nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008;452:633-7.
4. Esplen MJ, Madlensky L, Aronson M, Rothenmund H, Gallinger S, Butler K, Toner B, Wong J, Manno M, McLaughlin J. Colorectal cancer survivors undergoing genetic testing for hereditary non-polyposis colorectal cancer: Motivational factors and psychosocial functioning. Clinical Genetics. 2007;72(5):394-401.
5. Zanke B, Greenwood C, Rangrej J, Kustra R, Tenesa A,, Farrington S, Prendergast J, Olschwang S, Chiang T, Crowdy E, Ferretti V, Laflamme P, Sundararajan S, Roumy S, Olivier J, Robidoux F, Sladek R, Montpetit A, Campbell P, Bezieau S, O’Shea A, Zogopoulos G, Cotterchio M, Newcomb P, McLaughlin J, Younghusband B, Green R, Green J, Porteous M, Campbell H, Blanche H, Sahbatou M, Tubacher E, Bonaiti-Pellié C, Buecher B, Riboli E, Kury S, Chanock S, Potter J, Thomas G, Gallinger S, Hudson T, Dunlop M. A Colorectal Cancer Susceptibility Locus on Chromosome 8q24 Identified by a Genome-Wide Association Scan. Nature Genetics. 2007;39(8):989-94.